The Effects of Probiotic Supplementation on Glycemic index, Lipid Profiles and Inflammatory cytokines in NAFLD Patients: A Protocol for a Systematic Review and Meta-Analysis

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic disorders worldwide. In an aggressive type, non-alcoholic steatohepatitis (NASH) might lead to cirrhosis and hepatocellular carcinoma progression. Currently, there no certified drug applied treat NASH. Human studies have demonstrated beneficial effects probiotics supplementation in NAFLD. Due lack appropriate emerging requirements for further illustration over on treatment NAFLD NASH-related humans, this study, we seek evaluate matter often papered over. Methods: We will search PubMed, EMBASE, Cochrane Library, Web Science from inception February 2021. Search terms are keywords medical subject headings related NAFLD, probiotics, glycemic indexes, inflammation, dyslipidemia. 2 researchers determine strategy after several pre-searches. The Glycemic outcomes include glycated hemoglobin, fasting blood glucose, insulin, homeostasis model assessment insulin resistance. lipidomic differences High-density lipoprotein, Low-density Total triglyceride, cholesterol. Inflammatory IL6, IL1β, TNFα, CRP. meta-analysis be performed using END NOTE STATA. Results: Our study systematically effectiveness safety patients. Conclusion: This study’s results give proof supplements provide evidence clinical treatment.